Commander Zarc and the Mind Flayer
The ending of this battle isn’t all that far-fetched, but it’s still memorable for two reasons. The boss, Commander Zarc, drops a unique weapon, and countless players have been trying to get their hands on it since the early access days.
This battle takes place during the prologue. And while your goal is simply to escape the Nautiloids, a one-on-one with Commander Zarc and the Mind Flayer is an opportunity to acquire powerful starting weapons. The Mind Flayer will become hostile, so you will need to defeat both of them, not just Zarc. If Zarc falls. What’s more, the Cambion is also following you, and you have a turn limit before your ship crashes. Success earns him the Everburn Blade, one of the best early game weapons for Paladins, Barbarians, and Fighters.
Needless to say, this is your first real challenge in Baldur’s Gate 3 and sets the stage for the rest of your adventure. This makes Commander Zarc and Death of the Mind Flayer worth adding to the list.